Coordination-driven self-assembly of discrete Ru-Pt prismatic cages.

The coordination-driven self-assembly of two new Ru-Pt hexanuclear trigonal prismatic cages comprising arene-ruthenium(II) clips ( and ) and a tritopic platinum(II) metalloligand has been performed in methanol at room temperature. The [3 + 2] hexanuclear cages and were isolated in good yields and characterized by well-known spectroscopic techniques including multinuclear NMR, mass spectrometry, UV-vis and infrared studies. Geometry optimization revealed the shapes and sizes of these hexanuclear prismatic cages.

Coordination-driven self-assembly of ruthenium(ii) architectures: synthesis, characterization and cytotoxicity studies.

Coordination-driven self-assembly of organometallic η6-arene ruthenium(ii) supramolecular architectures (MA1-MA4) was carried out by employing dinuclear ruthenium acceptors [Ru2(μ-η4-C2O4)(CH3OH)2(η6-p-cymene)2](CF3SO3)2 (Rua), [Ru2(μ-η4-C6H2O4)(CH3OH)2(η6-p-cymene)2](CF3SO3)2 (Rub), [Ru2(dhnq)(H2O)2(η6-p-cymene)2](CF3SO3)2 (Ruc) and [Ru2(dhtq)(H2O)2(η6-p-cymene)2](CF3SO3)2 (Rud) separately with a new tetratopic donor (TD) in methanol at room temperature [TD = N,N,N',N'-tetra(pyridin-4-yl)-[1,1'-biphenyl]-4,4'-diamine]. All the coordination architectures were characterized by using spectroscopic techniques. The potency of these self-assembled architectures against human cervical cancer HeLa and human lung adenocarcinoma A549 cell lines is explored in vitro using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), annexin V-FITC/PI and 2',7'-dichlorofluorescein-diacetate assays.

Self-Assembly of Discrete Ru Molecular Cages and Their in Vitro Anticancer Activity.

Four new octanuclear Ru(II) cages (OC-1-OC-4) were synthesized from dinuclear p-cymene ruthenium(II) acceptors [Ru(μ-η-CO)(CHOH)(η-p-cymene)](OSCF) (A), [Ru(μ-η-CHO)(CHOH)(η-p-cymene)](OSCF) (A), [Ru(dhnq)(HO)(η-p-cymene)](OSCF) (A), and [Ru(dhtq)(HO)(η-p-cymene)](OSCF) (A) separately with a tetradentate pyridyl ligand (L) in methanol using coordination-driven self-assembly [L= N,N,N',N'-tetra(pyridin-4-yl)benzene-1,4-diamine]. The octanuclear cages are fully characterized by various spectroscopic techniques including single-crystal X-ray diffraction analysis of OC-4. The self-assembled cages show strong in vitro anticancer activity against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines as observed from the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.