A Comprehensive Review of Myocardial Bridging: Exploring Diagnostic and Treatment Modalities.

Myocardial bridging (MB) is a congenital coronary artery anomaly involving an overlying myocardium's partial or complete encasement of a coronary artery segment. The obstruction can lead to significant cardiac symptoms, resulting in myocardial ischemia, arrhythmia, and sudden cardiac death. Several approaches, including invasive and non-invasive methods, have been proposed to diagnose and manage MB.

High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis.

High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and progression of breast cancer is essential, as it will enable us to identify the role of dietary modification in preventing and managing the disease.

3D CRISPR screen in prostate cancer cells reveals PARP inhibitor sensitization through TBL1XR1-SMC3 interaction.

Poly(ADP-ribose) (PAR) polymerase inhibitors (PARPi) either have been approved or being tested in the clinic for the treatment of a variety of cancers with homologous recombination deficiency (HRD). However, cancer cells can develop resistance to PARPi drugs through various mechanisms, and new biomarkers and combination therapeutic strategies need to be developed to support personalized treatment. In this study, a genome-wide CRISPR screen was performed in a prostate cancer cell line with 3D culture condition which identified novel signals involved in DNA repair pathways.

Molecular Markers of Pancreatic Cancer: A 10-Year Retrospective Review of Molecular Advances.

Pancreatic cancer remains the third leading cause of death amongst men and women in the United States. Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer maintains its reputation of being the most aggressive with a poor prognosis. One of the contributing factors to the high mortality of PDAC is the absence of biomarkers for early detection of disease and the complexity of tumor biology and genomics.

The Use of Cannabis and Its Effects on Postpartum Depression.

Cannabis use and depression management have been studied, with a preponderance of exacerbating effects, but there are few studies on postpartum depression (PPD). Depression affects a significant number of women, with a portion of it manifesting as PPD in childbearing women in the United States each year. The pharmacologic management approaches have disadvantages such as side effects, cost-benefit ratio, contraindications, use reluctance, medication adherence, and stigmatization in patients.

: Unutilized natural medicine and promising future solution to emerging diseases in Africa.

is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea. It was known as "God's herb" in ancient China as it was believed to prolong life, enhance the youthful spirit and sustain/preserve vitality. is seldom collected from nature and is substantially cultivated on wood logs and sawdust in plastic bags or bottles to meet the international market demand.

Approaches to Medication Administration in Patients With Lack of Insight.

Lack of insight typically complicates psychiatric presentations, necessitating careful thought and planning to choose the best course of treatment. Exploring methods of medication administration techniques in the context of a lack of insight is crucial to achieving the ultimate goal of overcoming the insight barrier as rapidly as possible, which will result in therapeutic benefit. This study's objective was to systematically review the evidence on medication administration techniques in a backdrop of lack of insight and how that evidence was curated in the scientific literature.

The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.

Signals from retinal photoreceptors are processed in two parallel channels-the ON channel responds to light increments, while the OFF channel responds to light decrements. The ON pathway is mediated by ON type bipolar cells (BCs), which receive glutamatergic synaptic input from photoreceptors via a G-protein-coupled receptor signaling cascade. The metabotropic glutamate receptor mGluR6 is located at the dendritic tips of all ON-BCs and is required for synaptic transmission.

Genetic loci regulating cadmium content in rice grains.

Unlabelled: It has been estimated that up to 90% of human exposure to cadmium is through food, and that cadmium within rice grains can be a major contributor to that dietary source. In this study genome wide association mapping was conducted on the Bengal and Assam Aus Panel (BAAP) of rice to identify quantitative trait loci and candidate genes for lowering grain cadmium. Field experiments were conducted over two years under two different irrigation systems: continually flooded and alternate wetting and drying (AWD).

Epithelial Cell-Associated Galectin-3 Activates Human Dendritic Cell Subtypes for Pro-Inflammatory Cytokines.

There is mounting evidence that galectin-3 is a prognostic and diagnostic biomarker associated with diverse diseases and conditions, including cancer, cardiovascular disease, autoimmunity, wound healing, allergic disease, and chronic inflammation in general. Yet, whether and exactly how galectin-3 may participate in the pathogenesis of these diseases remains poorly understood. Recently, we have linked the expression of galectin-3 on the A549 epithelial cell line -an adenocarcinoma, to the activation of human basophils for the release of histamine and secretion of IL-4 and IL-13.

Erythropoietic potential of Parquetina nigrescens in cephalosporin-induced anaemia model.

is a folklore plant in Africa, particularly Nigeria, where its consumption is believed to stimulate red blood cells production. On this basis, the erythropoietic potential of the plant was evaluated in Cephalosporin-induced anaemia model, using Wistar rats as experimental subjects. Thirty-two male rats were randomly assigned to four groups (n = 8).

Protective role of apple cider vinegar (APCV) in CCl-induced renal damage in wistar rats.

Background: Apple Cider Vinegar, (APCV) has been locally associated with a number of health benefits, including protection against oxidative stress and related ailments. It is on this background the present study assessed its protective effects against carbon tetrachloride (CCl)-induced oxidative damage in kidneys of rats.

Methods: Twenty four adult rats of Wistar strain were randomly assigned to four groups (n = 6).

Toxicity and gas chromatography-mass spectrometry analyses of a polyherbal formulation commonly used in Ibadan metropolis, Nigeria.

A polyherbal formulation mainly composed of and Aloe barbadensis commonly patronized by some staff and students of a College Hospital in Ibadan, Nigeria was evaluated for its toxicity status and bioactive constituents. Its safety was assessed using acute and sub-chronic toxicity models in Wistar rats while Gas Chromatography-Mass Spectrometry (GC-MS) was used to identify the bioactive constituents. Findings showed that oral administration of the polyherbal formulation did not cause any notable behavioral changes or mortality in the animals during the acute toxicity testing.

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study.

Introduction: nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis as well as the histologic types at the University College Hospital, Ibadan, Nigeria.

Effect of variable thermal conductivity and viscosity on Casson nanofluid flow with convective heating and velocity slip.

This work investigates the effects of combined variable viscosity and thermal conductivity, nonlinear radiation and non-Darcian porous medium on a boundary layer MHD Casson nanofluid flow over a vertical flat plate with convective heating and velocity slip boundary conditions. The governing transport nonlinear partial differential equations and the boundary conditions are non-dimensionalized. The resulting system of coupled partial differential equations is then reduced to a set of coupled nonlinear ordinary differential equations using similarity transformation.

Galectin-3 is essential for IgE-dependent activation of human basophils by A549 lung epithelial cells.

Using novel co-culture model systems, galectin-3 is shown to facilitate basophil secretion of IL-4/IL-13, with implications that this unique mode of activation may be linked to a variety of diseases ranging from asthma to cancer.

Estimating the incidence of breast cancer in Africa: a systematic review and meta-analysis.

Background: Breast cancer is estimated to be the most common cancer worldwide. We sought to assemble publicly available data from Africa to provide estimates of the incidence of breast cancer on the continent.

Methods: A systematic search of Medline, EMBASE, Global Health and African Journals Online (AJOL) was conducted.

Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies.

Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and neuropathy which are collectively known as diabetic complications and are the principal actors in co-morbidity and eventual mortality often associated with diabetes.

Characterization of a new Hencken burner with a transition from a reducing-to-oxidizing environment for fundamental coal studies.

In pulverized coal burners, coal particles usually transition from a locally reducing environment to an oxidizing environment. The locally reducing environment in the near-burner region is due to a dense region of coal particles undergoing devolatilization. Following this region, the particles move into an oxidizing environment.

Toxicity status and antiulcerative potential of leaf extract in Wistar rats.

Aims: The lethal dose 50% (LD) and antiulcerative potentials of (ST) leaf extract were investigated.

Materials And Methods: LD was determined through two routes of administration (intraperitoneal [i.p] and oral [p.

The antioxidant and phenolic profiles of five green vegetables grown in Southern Nigeria.

Background: Regular consumption of vegetables has been associated with reduced risk of chronic diseases. The phenolic and free radical scavenging properties of five green vegetables grown in southern Nigeria were determined.

Methods: The phenolic and antioxidant profile of African spinach, bitter leaf, jute leaf, scent leaf and water leaf harvested in the month of August were assessed using standard protocols.

Effect of strong fragrance on olfactory detection threshold.

Objective: To assess the olfactory threshold of healthy volunteers at the University College Hospital, Ibadan and to investigate the effect of perfume on their olfactory detection thresholds.

Study Design: A quasi-experimental study on olfactory detection thresholds of healthy volunteers from September 2013 to November 2013.

Setting: Tertiary health institution.

Comparing Oxygen Saturation of Normal Children with that of Children with Adenotonsillar Hypertrophy.

To compare the nocturnal oxygen saturation profiles of children with adenotonsillar enlargement with that of normal children. A 1 year comparative study. The study was carried out at the Otorhinolaryngology Ward of the University College Hospital Ibadan.

Prevalence of otomycosis in Ibadan: a review of laboratory reports.

Otomycosis has typically been described as fungal infection of the external auditory canal with infrequent complications involving the middle ear. Because of the dearth of data on the prevalence of Otomycosis in this environment and increased rate of immunosuppression, this study was aimed at finding the prevalence and fungal etiological agents responsible for this condition. Aretrospective review of the laboratory reports of ear swabs of patients that presented with signs and symptoms suggestive of fungal infections of the ear like otorrhoea, otalgia and aural fullness were done.

Novel management of cervical necrotising fasciitis in a developing country: case report.

Objective: We report a rare case of cervical necrotising fasciitis arising from poorly managed acute tonsillitis.

Case Report: A 23-year-old woman presented with a two-week history of fever and an eight-day history of painful neck swelling. Nine days before presentation, she had received digital manipulation of her throat by a neighbour, which had worsened her throat pain.