Background: Thrombospondin-1 (TSP-1) is functionally important to intimal hyperplasia (IH) development. Statin drugs have beneficial pleiotropic effects, including reduced IH; however, the effect of statins on IH in a TSP-1-independent setting is unknown.
Hypothesis: Statins will be less effective in attenuating IH after vascular injury in TSP-1-null (Thbs1) mice compared with wild-type (WT) mice.