Publications by authors named "Adeniji A Johnson"
Using a metagenomic sequencing approach on stool samples from children with Acute Flaccid Paralysis (AFP), we describe the genetic diversity of Sapoviruses (SaVs) in children in Nigeria. We identified six complete genome sequences and two partial genome sequences. Several SaV genogroups and genotypes were detected, including GII (GII.
View Article and Find Full Text PDFHuman astrovirus (HAstV) is a nonenveloped RNA virus and has been implicated in acute gastroenteritis among children and elderly. However, there exists a substantial dearth of information on HAstV strains circulating in Nigeria. Viral-like particles were purified from archived 254 stool samples of children with acute flaccid paralysis between January and December 2020 from five states in Nigeria, using the NetoVIR protocol.
View Article and Find Full Text PDFDengue is often misclassified and underreported in Africa due to inaccurate differential diagnoses of nonspecific febrile illnesses such as malaria, sparsity of diagnostic testing and poor clinical and genomic surveillance. There are limited reports on the seroprevalence and genetic diversity of dengue virus (DENV) in humans and vectors in Nigeria. In this study, we investigated the epidemiology and genetic diversity of dengue in the rainforest region of Nigeria.
View Article and Find Full Text PDFObjective: This cross-sectional study investigated the circulating strains of rotavirus and screened for noravirus in Ibadan, Nigeria as the country introduces the rotavirus vaccine into its national immunization program.
Methods: Sixty-five stool samples were collected from children younger than 5 years with clinically diagnosed diarrhea and screened for the presence of rotavirus and norovirus using RT-PCR. Rotavirus-positive samples were further analyzed to determine the G and P genotypes using semi-nested multiplex PCR.
Article Synopsis
- A lot of money has been spent on studying the COVID-19 virus in Africa, leading to over 100,000 virus samples being analyzed to understand the spread of the disease.
- *More countries in Africa are now able to do these studies themselves, which helps them get results faster and keep a close watch on the virus.
- *To keep fighting COVID and other diseases, more funding and support for testing and research in Africa is really important for the future.
Rotavirus is the leading cause of viral gastroenteritis worldwide, and sewage is a major source of the virus dissemination in the environment. Our aim was to detect and genotype rotaviruses from sewages in Nigeria. One hundred and ninety sewage samples were collected between June 2014 and January 2015.
View Article and Find Full Text PDFArticle Synopsis
- - Northern Nigeria has the highest global rates of confirmed wild polio viruses, with concerns that the disease could spread to neighboring countries, especially due to missed deadlines for eradication efforts.
- - A study assessed polio virus neutralizing antibody levels in children from North-central and South-western Nigeria, revealing that herd immunity was alarmingly low in Ilorin (1.4%) but higher in Ibadan (36.6% and 49.5% at two hospitals).
- - Out of 299 children studied, 16.4% had no protection against any poliovirus serotypes, while 33.4% were fully protected; these findings highlight the need for better vaccination monitoring and effective public health policies.
Objectives: We investigated the antibody level of children against wild measles virus in view of recurrent measles epidemics, in order to provide information on immunization status for health policies and for the global measles mortality reduction initiative.
Methods: Two hundred and seventy-three children between the ages of 10 months and 13 years were recruited for this study from three hospital facilities in south-west and north-central Nigeria. Serum samples were collected from February to July 2009, and laboratory examination commenced in August of the same year.