Publications by authors named "Adem Milletsever"
Background: The adverse effects of radiotherapy (RT) primarily occur through oxidative stress, and attempts are being made to mitigate these effects. L-Carnitine (L-Car) involved in physiological functions, possesses antioxidant and tissue-protective properties. The goal of this investigation is to appraise the radioprotective efficacy of L-Car supplementation.
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- Inflammation and oxidative stress contribute significantly to lung injury caused by cardiac ischemia, and CBD shows potential in protecting lung tissue through its antioxidant and anti-inflammatory properties.
- The study involved 40 male rats divided into four groups, where researchers induced cardiac ischemia and subsequently analyzed lung tissues for various stress and injury indicators.
- Results indicated significant lung damage in the ischemia group, but both preventive (p-CBD) and therapeutic (t-CBD) treatments with CBD effectively mitigated this damage, restoring normal levels in various tests.
Article Synopsis
- * A study on female rats examined the effects of cannabidiol (CBD) on neuroinflammation by dividing them into four groups, including those receiving lipopolysaccharide (LPS) and CBD treatments.
- * Results showed that CBD treatment improved neuron survival and reduced oxidative stress by regulating various proteins and synthesis pathways, reversing the damaging effects caused by LPS exposure.
The effects of cannabidiol against Methotrexate-induced lung damage.
Basic Clin Pharmacol Toxicol
May 2024
Article Synopsis
- Methotrexate (MTX) is an effective cancer treatment but can cause lung damage, prompting research into cannabidiol (CBD) as a protective agent.
- In an experiment with Wistar Albino rats, MTX treatment resulted in significant lung damage characterized by inflammation and cell loss, confirmed through various analytical methods.
- CBD treatment showed potential in reversing the lung damage caused by MTX, suggesting CBD may serve as a therapeutic option to protect against such adverse effects.
High-fructose corn syrup (HFCS) has been a subject of intense debate due to its association with cardiovascular risks. This study investigates the potential protective effects of selenium (Se) supplementation against cardiac damage induced by HFCS. Thirty-two male Wistar albino rats were divided into four equal groups: control, CS (20%-HFCS), CS with Se (20%-HFCS, 0.
View Article and Find Full Text PDFObjectives: Cisplatin (CP) is frequently used in various types of cancers. The cardiotoxic effects of this agent limit its usage. Our study seeks to investigate the protective effects of Irbesartan (IRB) on CP-induced cardiotoxicity.
View Article and Find Full Text PDFDoxorubicin (DOX), which is used to treat various cancers and hematological malignancies, has limited therapeutic application due to its toxicity in tissues and organs. These toxic effects occur through alterations in intracellular calcium regulation, elevated cell stress and oxidative damage, and increased apoptosis. Lercanidipine (LRD) is a long-acting antihypertensive calcium channel blocker with anti-inflammatory, anti-apoptotic, and antioxidant effects.
View Article and Find Full Text PDFOnly ultraviolet-C (UV-C) from UV lights, which are emitted by the sun and absorbed by the atmosphere's ozone layer, does not reach the Earth's surface. UV-C is a powerful disinfection method that is commonly used to sterilize fluids, air, and surfaces. There is a little knowledge of the effects of UV-C radiation on living bodies.
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