In Silico and in Vitro Biological Evaluation of Novel Serial Sulfonate Derivatives on Pancreatic Lipase Activity.

The novel benzothiazole sulfonate hybrid derivatives containing azomethine group were synthesized and characterized using H-NMR, C-NMR, and HR-MS analysis. The potential enzyme inhibition activities against pancreatic lipase of the novel benzothiazole sulfonate hybrid derivatives containing azomethine group were screened with in vitro and in silico methods. IC values of compounds 5 b (23.

Design, synthesis, spectroscopic characterizations, pancreatic lipase as well as tyrosinase inhibition evaluations and analysis of novel aryl sulfonate-naphthalene hybrids.

One of the primary purposes of this study is to synthesize new aryl sulfonate-naphthalene hybrid structures possessing divergent electron-withdrawing and electron-releasing functional groups. Following the improved reaction conditions, we successfully gathered ten distinct sulfonate derivatives () with good yields. The synthesized naphthalene-based sulfonate derivatives were then characterized using appropriate analytical methods (FT-IR, H-NMR, C-NMR, HRMS, and elemental analysis).

Synthesis, Biological Activity and Molecular Docking Studies of Novel Sulfonate Derivatives Bearing Salicylaldehyde.

Enzyme activity alterations have been associated with many metabolism disorders and have crucial roles in the pathogenesis of some diseases. Tyrosinase is a key enzyme in melanin biosynthesis, which is responsible for skin pigmentation to protect the skin from solar radiation. Pancreatic lipase has been considered a key enzyme for the treatment of obesity.

A novel oligo-pyrazole-based thin film: synthesis, characterization, optical and morphological properties.

Pyrazole-3,4-dicarboxylic acid was synthesized via the hydrolysis of pyrazole-3-carboxylic acid and subsequently heated with thionyl chloride to give the novel pyrazole-3,4-dicarbonyl dichloride , which was easily converted into oligo-pyrazole upon its reaction with -phenylene-diamine. These newly synthesized compounds were characterized by H-NMR, C-NMR, and FT-IR spectroscopy, and gel permission chromatography (GPC). Three novel oligo-pyrazole thin films were prepared using oligo-pyrazole with these respective values of thickness: 20, 21, and 24 μm.