ApA Regulates Directional Mobility and Antigen Presentation in Dendritic Cells.

The significance of intracellular ApA levels over immune activity of dendritic cells (DCs) has been studied in Nudt2/CD11c-cre mice. The transgenic mice have been generated by crossing floxed NUDT2 gene mice with DC marker CD11c recombinase (cre) mice. The DCs derived from these mice have higher levels of ApA (≈30-fold) compared with those derived from Nudt2 mice.