Publications by authors named "Adeline Schmitt"
Metal ion-catalyzed overproduction of reactive oxygen species (ROS) is believed to contribute significantly to oxidative stress and be involved in several biological processes, from immune defense to development of diseases. Among the essential metal ions, copper is one of the most efficient catalysts in ROS production in the presence of O2 and a physiological reducing agent such as ascorbate. To control this chemistry, Cu ions are tightly coordinated to biomolecules.
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- Azomethine imines are useful in chemical synthesis but usually need anhydrous conditions; this study introduces cyclic-acyl azomethine imines (AMIs) that work well in water.
- These AMIs are stable in biological settings and react quickly with isonitriles, even in the presence of biological molecules like thiols.
- The research shows that the AMI-isonitrile reactions are biocompatible and can effectively label proteins without interfering with other bioorthogonal reactions.
The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity.
View Article and Find Full Text PDFCapture and release of peptides is often a critical operation in the pathway to discovering materials with novel functions. However, the best methods for efficient capture impede facile release. To overcome this challenge, we report linkers based on secondary amino alcohols for the release of peptides after capture.
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- C-substituted proline derivatives help create functional collagen peptides, but their stereochemistry can lead to unwanted limitations.
- Alkylated γ-azaproline (γ-azPro) derivatives, which mimic proline, are advantageous because they lack stereogenic centers and can easily change shape due to nitrogen invertibility.
- Studies using NMR and DFT methods revealed that γ-azPro derivatives can adopt various conformations and maintain thermal stability when integrated into collagen peptides, whether in the Xaa or Yaa positions.