Benign Pneumatosis Intestinalis in a Patient With Symptomatic COVID-19.

The pathophysiology of pneumatosis intestinalis (PI) is poorly understood. PI can be associated with COVID-19 infection. Although this relationship is unclear, proposed mechanisms include direct viral invasion of the mucosa, the use of IL-6 inhibitors, and bowel ischemia.

Lysosomal dysfunction in diabetic cardiomyopathy.

Diabetes is a major risk factor for a variety of cardiovascular complications, while diabetic cardiomyopathy, a disease specific to the myocardium independent of vascular lesions, is an important causative factor for increased risk of heart failure and mortality in diabetic populations. Lysosomes have long been recognized as intracellular trash bags and recycling facilities. However, recent studies have revealed that lysosomes are sophisticated signaling hubs that play remarkably diverse roles in adapting cell metabolism to an ever-changing environment.