Publications by authors named "Adeline Baron"
Article Synopsis
- Many manufacturers have created new kits for quantifying plasma HIV-1 RNA, and a recent kit combining the ELITe InGenius® instrument with the HIV1 ELITe MGB® kit has been launched globally.
- The study aimed to compare the clinical performance of this new kit with Hologic's Aptima® HIV-1 Quant Dx kit using a variety of HIV-1 samples to assess linearity, specificity, and sensitivity.
- Results showed that the two kits had an overall agreement of 83.7%, with slight differences in detection rates, but both were effective for monitoring viral load in patients with different HIV-1 strains.
Performance Analysis of Three Commercial Kits Designed for RNA Quantification of HIV-1 Group O Variants.
J Acquir Immune Defic Syndr
October 2021
Background: The genetic divergence of HIV-1 group O is high relative to pandemic group M, which could impact detection and quantification of plasma RNA. Recent commercial kits for RNA quantification seem to show good performances in HIV-1/O, but discrepancies are still observed. Here, we compare the performances of 3 commercial assays for the RNA quantification of HIV-1/O.
View Article and Find Full Text PDFBackground: Measurement of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) viral loads is commonly used to monitor posttransplant patients. Two new systems (eMAG/eSTREAM and Versant/kPCR) have been recently commercialized.
Objectives: To evaluate the performance of four systems to quantify CMV and EBV in whole blood.
Objective: To evaluate the quantification performance of the new Cepheid GeneXpert HIV-1 viral load assay, on a wide panel of HIV-1 variants.
Methods: Clinical performance was evaluated relative to the Abbott RealTime HIV-1 assay on 285 HIV-1 seropositive samples selected to cover the assays quantification range (40 copies/mL-10,000,000 copies/mL), and included RNA undetectable or detected seropositive samples. The panel comprised 120 subtype B, 150 non-B, and 15 nontypable clinical samples; serial dilutions of 18 viral supernatants representative of the divergent viruses of HIV-1 groups N, O, and P were also tested.