Lancet
May 2015
Background: The optimum duration of first-line treatment with chemotherapy in combination with bevacizumab in patients with metastatic colorectal cancer is unknown. The CAIRO3 study was designed to determine the efficacy of maintenance treatment with capecitabine plus bevacizumab versus observation.
Methods: In this open-label, phase 3, randomised controlled trial, we recruited patients in 64 hospitals in the Netherlands.