Publications by authors named "Adelaide da Conceicao Passos"
Aggression is a set of complex behaviors commonly described in different neurological disorders, such as schizophrenia, autistim spectrum disorder, and anxiety. Previous studies have described that some changes in the redox status of the brain are closely associated with aggressive behavior in different species. In addition, the endocannabinoid system acts as a neuromodulator of the central nervous system, however, its participation in aggressive behavior needs to be elucidated.
View Article and Find Full Text PDFPutative Activation of the CB1 Cannabinoid Receptors Prevents Anxiety-Like Behavior, Oxidative Stress, and GABA Decrease in the Brain of Zebrafish Submitted to Acute Restraint Stress.
Waldo Lucas Luz Mateus Santos-Silva Patrick Bruno Cardoso Nadyme Assad Edinaldo Rogério da Silva Moraes Adelaide da Conceição Passos
Front Behav Neurosci
January 2021
Article Synopsis
- Anxiety disorder is linked to acute stress, with oxidative stress and GABA dysfunction playing key roles in its development.
- Cannabinoid receptors, specifically CB1 receptors, can reduce anxiety-like behavior in animal models, and their stimulation was tested on zebrafish undergoing acute restraint stress.
- The study found that activating CB1 receptors with ACEA not only reduced anxiety-like behaviors but also mitigated oxidative stress and maintained GABA levels in the zebrafish brain, suggesting a new potential treatment pathway for anxiety disorders.
Article Synopsis
- Acute stress significantly contributes to the onset of anxiety disorders, and zebrafish are commonly used to study the brain's response to stress and anxiety.
- The research focused on how acute restraint stress affects cell activation in the telencephalon of adult zebrafish, revealing reduced c-fos protein expression and lower GABA release following stress.
- The findings suggest that decreased GABA levels lead to less activation of GABAA receptors, resulting in heightened anxiety-like behavior, and indicate zebrafish may be useful for testing anxiolytic drugs targeting the GABAergic system.