Increase of activity of tioconazole against resistant microorganisms by the addition of butylated hydroxyanisole.

Tioconazole (TCZ) killed resistant Candida albicans in less than 3 min, after the addition of butylated hydroxyanisole (BHA), a phenolic antioxidant, at subinhibitory concentrations. The bactericidal activity was also rapid against resistant Escherichia coli. BHA increased the TCZ activity in RPMI 1640 medium 18 times against ten strains of resistant C.