Publications by authors named "Adelaide Sterlin"
Neonates respond to hypoxia initially by increasing ventilation, and then by markedly decreasing both ventilation (hypoxic ventilatory decline) and oxygen consumption (hypoxic hypometabolism). This latter process, which vanishes with age, reflects a tight coupling between ventilatory and thermogenic responses to hypoxia. The neurological substrate of hypoxic hypometabolism is unclear, but it is known to be centrally mediated, with a strong involvement of the 5-hydroxytryptamine (5-HT, serotonin) system.
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- * The study introduces a three-step in vitro assay to assess the effects of rare CFTR mutations, involving visualization of protein trafficking in cells and analysis of CFTR function.
- * By studying six rare mutations, five of which were identified in the lab, the researchers found that correlating cellular effects with patient clinical data could enhance genetic counseling for cystic fibrosis.