Publications by authors named "Adelaide Carrara"
KBG syndrome is a rare genetic disorder caused by heterozygous pathogenic variants in ANKRD11. Affected individuals have developmental delay, short stature, characteristic facial features, and other dysmorphic findings. To date, a spectrum of unspecific neuroradiological defects has been reported in KBG patients, such as cortical defects, white matter abnormalities, corpus callosum, and cerebellar vermis hypoplasia.
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- Depression is a widespread mental disorder linked to significant socio-economic issues, but the underlying biological mechanisms are not well understood.
- The gut microbiota plays a crucial role in regulating brain function through the gut-brain axis, where an imbalance can negatively impact mental health and cognitive abilities.
- Strategies like probiotics and dietary changes, particularly the Mediterranean diet, show potential for enhancing depression treatments by restoring gut balance and improving the effectiveness of antidepressants.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, the therapeutic approach still has limited efficacy in clinical practice. Oxidative stress (OS) has been established as an early driver of several age-related diseases, including neurodegeneration.
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- * Oxidative stress results from an imbalance between harmful pro-oxidants and beneficial antioxidants, and is a key driver of cellular senescence.
- * The text reviews different types of antioxidants, including vitamins and flavonoids, that could potentially combat oxidative stress and help delay aging, highlighting a need for further comprehensive research in this area.
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain. Although several studies have been conducted to unravel the complex and interconnected pathophysiology of AD, clinical trial failure rates have been high, and no disease-modifying therapies are presently available. Fluid biomarker discovery for AD is a rapidly expanding field of research aimed at anticipating disease diagnosis and following disease progression over time.
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