Publications by authors named "Adela Patcas"
Bosn J Basic Med Sci
February 2022
Article Synopsis
- Precision medicine in lung cancer research has led to improved patient survival and quality of life, especially through targeted therapies for non-small cell lung cancer (NSCLC) with ALK gene rearrangement.*
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- This review highlights ALK tyrosine kinase inhibitors (TKIs), their mechanisms of action and resistance, various gene detection methods, and future research aimed at overcoming resistance.*
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- Crizotinib was the first approved TKI and while newer drugs like alectinib and brigatinib have been developed, resistance remains a significant challenge with half of the resistance mechanisms still unidentified.*
