Publications by authors named "Adela Orellana"
Article Synopsis
- mLOY (mosaic loss of chromosome Y) is linked to aging and has associations with Alzheimer's disease (AD), but its influence can be misinterpreted due to age factors in studies.
- Using Mendelian randomization, researchers created a polygenic risk score (mloy-PRS) that accounts for age, revealing a significant increase in mLOY risk that is independent of age.
- Results indicate that higher genetic risk for mLOY correlates with quicker AD progression in men with mild cognitive impairment, while showing no impact on women, and suggesting mLOY plays a role in the development of AD.
Article Synopsis
- The study investigates the prevalence of amyloid aggregation, a key feature of Alzheimer's disease, in individuals with varying cognitive statuses, including those with normal cognition and who have clinical AD dementia.
- It analyzes how factors like age, sex, educational background, and the method of detecting amyloid (CSF or PET scans) influence the prevalence estimates.
- Data were collected from 85 study cohorts between 2013 and 2020, using a systematic approach to categorize amyloid measurements as normal or abnormal.
Article Synopsis
- Alzheimer's disease (AD) is the leading type of dementia, affecting 35 million people globally, with the APOE ε4 allele significantly increasing the risk of late-onset AD.
- The ADAPTED consortium conducted a comprehensive analysis using various OMICS technologies to explore the effects of APOE on AD, identifying relevant genes and pathways both influenced by and independent of APOE.
- The study discovered a set of biomarkers that display contrasting profiles in plasma and brain for different AD cases, which could help develop blood tests for the disease, highlighting the effectiveness of integrating multiple OMICS data for better understanding AD.
Background: The COVID-19 pandemic has brought great disruption to health systems worldwide. This affected ongoing clinical research, particularly among those most vulnerable to the pandemic, like dementia patients. Fundació ACE is a research center and memory clinic based in Barcelona, Spain, one of the hardest-hit countries.
View Article and Find Full Text PDFBackground: Computerized neuropsychological tests for early detection of Alzheimer's disease (AD) have attracted increasing interest. Memory for faces and proper names is a complex task because its association is arbitrary. It implicates associative occipito-temporal cerebral regions, which are disrupted in AD.
View Article and Find Full Text PDFJanus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity.
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