The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats.

Background: Diabetic nephropathy (DN) is a common vascular complication of diabetes Miletus (DM) that require weight control and dietary restrictions, especially for protein. A protein-restricted diet with ketoacid analogs (KA) reduces the intake of nitrogen while avoiding the harmful consequences of inadequate dietary protein intake.

Objective: This study aimed to investigate the efficacy and safety of a protein-free diet with ketoacid analogs in chronic kidney disease (CKD)-affected diabetic rats.