Publications by authors named "Adel Rashad Abd-Allah"
The SARS-CoV-2 infection activates host kinases and causes high phosphorylation in both the host and the virus. There were around 70 phosphorylation sites found in SARS-CoV-2 viral proteins. Besides, almost 15,000 host phosphorylation sites were found in SARS-CoV-2-infected cells.
View Article and Find Full Text PDFSnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors.
Int Immunopharmacol
September 2020
The infiltration of immune cells is a hallmark of most forms of malignancy. It is well known that in Tumor Microenvironment (TME), monocytes undergo reprogramming process to differentiate into Tumor Associated Macrophages (TAMs) (M2 macrophages). Interestingly, this reprogramming process depends on signals provided by tumors.
View Article and Find Full Text PDFArticle Synopsis
- * The study identifies the transcription factor GATA3, which is highly expressed in HGSOC but not in the fallopian tube, as a key player in these processes; its presence correlates with poor patient outcomes and enhances cancer cell proliferation and migration.
- * Targeting GATA3 in TAMs has shown promise in reducing tumor growth, chemoresistance, and angiogenesis in HGSOC, suggesting that GATA3 could be a valuable prognostic marker and therapeutic target
In 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability.
View Article and Find Full Text PDF