Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters.

In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects.

Subcellular toxicity of gold nanoparticles irradiated with 532 nm pulsed laser.

Objective: Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser, we explored some subcellular events that may threaten the viability of rat kidney cells (RKCs) incubated with GNPs irradiated with pulsed laser.

Background Data: We have previously shown a decrease in the viability of RKCs, on incubation with GNPs irradiated with pulsed laser. This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events.