Publications by authors named "Adel A Ibrahim"
The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study.
Medicina (Kaunas)
June 2023
Article Synopsis
- LGR5 is a significant stem cell marker in colorectal cancer (CRC) that enhances Wnt/Β-catenin signaling, making it a potential therapeutic target.
- The study examined tissue samples from normal colon, adenomas, and CRC to analyze the expression levels of LGR5 and Β-catenin using immunohistochemical techniques.
- Findings revealed that LGR5 was absent in normal tissues but showed higher expression in adenomas and CRC, indicating its potential role in cancer development and suggesting further exploration for therapeutic applications.
Background: Routine histopathological examination (RHPE) of all gallbladder specimens is required to detect the presence of gallbladder carcinoma (GBC) or any other pathology. The work aims to study the incidence and the clinical significance of detecting unusual gallbladder findings upon the RHPE of the referred cholecystectomy specimens to a histopathology laboratory section at a referral hospital in Saudi Arabia during one year period.
Materials And Methods: From May 2019 to May 2020, all histopathology reports of 444 consecutive gallbladder specimens after elective and emergency cholecystectomies were retrospectively analyzed and divided into two groups; usual findings and unusual findings which were reviewed blindly by two other pathology consultants.
Background: Despite the several studies suggesting the genetic basis of acne vulgaris, the exact genetic architecture of this very common condition is not yet clear.
Aim Of The Work: This study aimed to investigate the association between IL-1A (-889) gene polymorphism and acne vulgaris in a sample of patients.
Subjects And Method: Blood samples from 100 patients with acne vulgaris and 100 healthy age, sex, and BMI matched controls were obtained.
Gentamicin extended interval regimen and ototoxicity in neonates.
Int J Pediatr Otorhinolaryngol
August 2015
Objectives: To assess the extended interval regimen gentamicin associated ototoxicity in neonatal intensive care unit using hearing tests.
Methods: Two hundred and twenty neonates admitted to neonatal intensive care were assessed; 110 neonates who had received gentamicin and 110 neonates who had not received gentamicin served as control group. Gentamicin group were further subdivided according to the duration of treatment into 50 neonates who had received gentamicin for 5 days or less and 60 neonates who had received gentamicin for more than 5 days.
Purpose: This research was done to assess levels of psychosocial stress and related hazards [(burnout, depression, and posttraumatic stress disorder (PTSD)] among emergency medical responders (EMRs).
Materials And Methods: A comparative cross-sectional study was conducted upon (140) EMRs and a comparative group composed of (140) nonemergency workers. The groups studied were subjected to semistructured questionnaire including demographic data, survey for job stressors, Maslach burn out inventory (MBI), Beck depression inventory (BDI), and Davidson Trauma scale for PTSD.