Publications by authors named "Adegbenga O Otun"

Article Synopsis
  • The study focuses on using radiomic features from contrast-enhanced CT scans to distinguish between osteoradionecrosis (ORN) and normal mandibular bone in head and neck cancer patients treated with radiotherapy.
  • Data from 150 patients was analyzed, with feature extraction performed using PyRadiomics and a Random Forest classifier used to identify key features, resulting in an accuracy of 88%.
  • The findings highlight specific radiomic features that can differentiate ORN from healthy tissue, paving the way for future research on early detection and intervention strategies.
View Article and Find Full Text PDF

Objectives: We describe the development of 3D-printed stents using our digital workflow and their effects on patients enrolled in the lead-in phase of a multi-center, randomized Phase-II trial.

Materials And Methods: Digital dental models were created for patients using intraoral scanning. Digital processes were implemented to develop the mouth-opening, tongue-depressing, and tongue-lateralizing stents using stereolithography.

View Article and Find Full Text PDF

Purpose: Many head and neck cancer patients who receive radiation therapy experience radiation-induced dysgeusia (RID), which has no standard treatment. The only supplement controlled clinical trials have evaluated for the treatment of RID is zinc. However, the results of these and other studies investigating the use of zinc for RID have been inconsistent.

View Article and Find Full Text PDF

Background: COVID-19 pandemic has strained human and material resources around the world. Practices in surgical oncology had to change in response to these resource limitations, triaging based on acuity, expected oncologic outcomes, availability of supportive resources, and safety of health care personnel.

Methods: The MD Anderson Head and Neck Surgery Treatment Guidelines Consortium devised the following to provide guidance on triaging head and neck cancer (HNC) surgeries based on multidisciplinary consensus.

View Article and Find Full Text PDF

This report describes a case of osteonecrosis of the jaw developing after a routine dental extraction in a patient being treated with dasatinib, a tyrosine kinase inhibitor, for chronic myelogenous leukemia. As the role of tyrosine kinase inhibitors in cancer treatment expands, patterns of debilitating complications involving the osseous structures of the oral cavity have begun to emerge, and many long-term side effects of this promising therapy remain unknown. To limit the occurrence of known complications, health care providers and patients must be aware of the potential for serious complications of dasatinib, and appropriate protocols should be in place before administration of this medication.

View Article and Find Full Text PDF