Multidisciplinary management of chylous ascites following resection of a retroperitoneal, functional Paraganglioma.

Extra-adrenal, functional paraganglioma, if not medically controlled, requires early surgical resection. This can often be challenging when found in a retroperitoneal location, where resections are prone to lymphatic disruption and chyle leaks. Chylous ascites carry a significant risk of protein and caloric malnutrition, dehydration, and even mortality given the nutrient-rich characteristic of lost lymphatic fluid.

Effect of Virtual Reality and Musical Earplug Temporal Tap Technique in Reduction of Gag Reflex in Pediatric Patients.

Background: Gagging is a stimulated, protective reflex to prevent any material from entering the mouth or oropharynx. However, a hyperactive gag reflex is a common occurrence and anxiety-provoking stimulus while performing routine clinical procedures. Impression making is a clinical procedure that causes pronounced gagging and severe discomfort to the patient.

Evaluation of Microleakage and Shear Bond Strength of Two Different Calcium-based Silicate Indirect Pulp Capping Agents When Restored with Glass Ionomer Cement and Composite Resin Restoration: A Comparative Study.

Background: Indirect pulp therapy (IPT) is a conservative treatment approach that leaves the deepest caries adjacent to the pulp undisturbed in an effort to avoid pulp exposure. The result of IPT is primarily dependent on the biocompatibility, sealing capacity, adaptability of the overlying restoration to underlying dentin, and strength of the liner material utilized.

Aim: To evaluate shear bond strength (SBS) and microleakage of mineral trioxide aggregate (e-MTA) and biodentine when restored with glass ionomer cement (GIC) and composite resin after their initial set time.

Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations.

Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity in insects and human cells.

Improving the Consent Process for Superficial Abscesses Through Pre-printed Consent Forms.

Introduction Informed consent is essential to ensure that patients are appropriately educated about proposed procedures, including associated risks and potential benefits, to make a valid decision. Incision and drainage of an abscess is a common procedure performed by various healthcare professionals. Inconsistent practices in the consent process can lead to misunderstandings among the patient and have financial and legal complications for both the clinician and the hospital.

Current Role of Brivaracetam in the Management of Epilepsy in Adults and Children: A Systematic Review.

Epilepsy, a neurological condition, has a devastating effect on the quality of life (QoL) of patients if left untreated. Brivaracetam (BRV), a third-generation antiepileptic drug (AED), acts by modulating synaptic vesicle proteins, making it a valuable addition to the arsenal of drugs for epilepsy management. This study aims to assess the efficacy, safety, and reasons for switching from prior AEDs to BRV in patients with epilepsy.

Design, synthesis and biological evaluation of some imidazo[1,2-]pyridine derivatives as anti-tubercular agents: an in silico - approach.

In this study, we designed, synthesized and evaluated some novel imidazo[1,2-]pyridine derivatives as potential anti-TB agents. Preliminary screening for anti-TB activity of the synthesized compounds was performed against H37Rv strain using the microplate Alamar Blue assay (MABA). Network pharmacology was used to identify the possible targets and pathways of these compounds against Mtb infection.

Haematological setpoints are a stable and patient-specific deep phenotype.

The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals, undermining the precision medicine goal to tailor care for patients on the basis of their unique characteristics. Here we study thousands of diverse patients at an academic medical centre and show that routine CBC indices fluctuate around stable values or setpoints, and setpoints are patient-specific, with the typical healthy adult's nine CBC setpoints distinguishable as a group from those of 98% of other healthy adults, and setpoint differences persist for at least 20 years.

Mapping Structure and Rheology of pH-Responsive Resins for Low-VOC Coatings.

In recent years, the paint and coatings industry has shifted away from traditional resin formulations that require high concentrations of volatile organic compounds (VOCs) to achieve the desired rheological performance and sustainability targets. One approach to eliminate or reduce VOCs in paint and coating formulations while maintaining the final performance is to disperse stimuli-responsive polymer latex particles in water. The chemistry and architecture of these particles have been engineered such that the suspension rheology changes in response to the pH changes.

Predicting Early Hospital Discharge Following Revision Total Hip Arthroplasty: An Analysis of a Large National Database Using Machine Learning.

Background: Revision total hip arthroplasty (rTHA) was recently removed from the Medicare inpatient-only list. However, appropriate candidate selection for outpatient rTHA remains paramount. The purpose of this study was to evaluate the utility of a large national database using machine learning (ML) and traditional multivariable logistic regression (MLR) models in predicting early hospital discharge (EHD) (< 24 hours) following rTHA.

Effect of hand-wrist exercises on distal radius fracture healing based on markerless motion capture system.

With the internal volar locking plate (VLP) technique emerging as a preferred surgical approach, early post-surgery therapeutic exercises have shown promise in promoting wrist functionality after distal radial fractures (DRFs). The biomechanical microenvironment, particularly the role of biomechanical stimuli, plays a crucial role in guiding stem tissue formation at the fracture site. However, much less is known about how various hand exercises interact with the microenvironment and influence fracture healing outcomes.

Assessing the Repeatability of Inner Choroid Flow Deficit Percentage in Intermediate AMD and Controls: A Comparative Study between Different Post-processing Approaches.

Purpose: To assess repeatability of macular inner choroid flow deficit percentage (ICFD%) in intermediate age-related macular degeneration (iAMD) and controls employing various post-processing approaches.

Methods: Cross-sectional, observational study. We included (1) 22 iAMD and 24 control eyes, with (2) age >50 years, (3) visual acuity >20/32, and (4) no additional ocular and systemic confounders.

Imaging-guided bioresorbable acoustic hydrogel microrobots.

Micro- and nanorobots excel in navigating the intricate and often inaccessible areas of the human body, offering immense potential for applications such as disease diagnosis, precision drug delivery, detoxification, and minimally invasive surgery. Despite their promise, practical deployment faces hurdles, including achieving stable propulsion in complex in vivo biological environments, real-time imaging and localization through deep tissue, and precise remote control for targeted therapy and ensuring high therapeutic efficacy. To overcome these obstacles, we introduce a hydrogel-based, imaging-guided, bioresorbable acoustic microrobot (BAM) designed to navigate the human body with high stability.

Nucleo-cytoplasmic environment modulates spatiotemporal p53 phase separation.

Liquid-liquid phase separation of various transcription factors into biomolecular condensates plays an essential role in gene regulation. Here, using cellular models and in vitro studies, we show the spatiotemporal formation and material properties of p53 condensates that might dictate its function. In particular, p53 forms liquid-like condensates in the nucleus of cells, which can bind to DNA and perform transcriptional activity.

The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.

The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of this pore are characterized, the molecular identity of the pore-forming component remains elusive.

An institutional analysis of hospital readmission following a robotic pancreaticoduodenectomy.

This study sought to identify the primary reasons for hospital readmissions and examine patient outcomes and associated costs following readmission after robotic pancreaticoduodenectomy. We conducted a retrospective analysis of 435 patients who underwent robotic pancreaticoduodenectomy between 2012 and 2024. Readmitted patients within 30 days post-surgery were compared to non-readmitted patients using Student's t-test and Fisher's exact test.

Retrospective evaluation of post-surgical orchialgia in men undergoing no-scalpel vasectomy.

Introduction: Vasectomy is a form of permanent contraception in men that is safe and effective. Complications are relatively uncommon, although patients may experience postoperative pain. Current literature quotes a broad range in the incidence of chronic orchialgia following no-scalpel vasectomy from 0.

Characteristics and Resource Utilization of Hospitalized Children With Somatic Symptoms.

Objective: To examine patient characteristics and resource utilization of hospitalized children and adolescents with somatic symptom and related disorders (SSRDs).

Patients And Methods: This study included 173 patients who were aged 6 to 18 years and admitted to a single, tertiary academic children's hospital between April 2015 and December 2021 with a diagnosis of an SSRD. Sociodemographic information and clinical features were assessed as outcomes.

Echocardiography Findings for Pulmonary Hypertension During Workup for Bronchoscopic Lung Volume Reduction.

Bronchoscopic lung volume reduction (BLVR) is a minimally invasive intervention that improves dyspnea and quality of life in select individuals with emphysema. Echocardiography is the initial screening tool for pulmonary hypertension (PH) in patients evaluated for BLVR. Multiple BLVR and lung volume reduction surgery (LVRS) trials have used and right ventricular systolic pressure (RVSP) of 45 mm Hg as a cutoff for potential significant PH.

Maximising efficacy in HER2-positive breast cancer: immunoliposomal co-delivery of miR155 inhibitor and paclitaxel for targeted therapy.

Breast cancer, particularly the HER2 positive subtype, presents a formidable challenge in clinical oncology, necessitating innovative therapeutic strategies. Here, we present a novel immunoliposome-based formulation designed for targeted delivery of paclitaxel and miRNA inhibitors to HER2-positive breast cancer cells. Through a rigorous preclinical evaluation encompassing cellular studies and an tumor xenograft model, we demonstrate the formulation's remarkable efficacy in inhibiting cell proliferation, inducing apoptosis, and suppressing tumor growth.

A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment.

Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation of NLCs, the article emphasizes their suitability for targeted drug delivery.