Publications by authors named "Adeesha S Jayathilaka"
Beclomethasone dipropionate (1) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergy properties. It is widely used to treat asthma, allergic rhinitis, and dermatoses. However, existing synthetic routes to this active pharmaceutical ingredient (API) contain steps resulting in low and/or inconsistent yields, and use obsolete reagents.
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- The synthesis of levothyroxine sodium, a crucial treatment for hypothyroidism, has relied on outdated methods that are inefficient and lack detailed data on intermediates.
- The authors propose a revamped synthesis using modern reagents, improving yields to 39-51% by modifying the original Chalmers synthesis.
- Their improved methodology includes a more effective N-acetylation step and offers practical guidance for producing levothyroxine sodium in laboratory and industrial settings.