Publications by authors named "Adediwura Arowosegbe"
Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to assess the acceptability and effectiveness of CDKs in preventing infections in deliveries attended by traditional birth attendants (TBAs) in Abeokuta, Nigeria.
Methods: The study was a cluster-randomized trial with 67 birth centres/clusters, 453 births/mothers, and 457 babies randomized to intervention or control arms; intervention involved supplementation of delivery with JANMA CDKs.
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study temporal events in pancreatic islets in LEW.1WR1 rats, in which autoimmune diabetes can be induced with virus infection, by performing transcriptional analysis of islets harvested during the prediabetic period.
View Article and Find Full Text PDFAim: To investigate hand-dug well water used for drinking and domestic purposes in a rural community in Southwest Nigeria for water safety and fungal presence as well as to determine the antifungal resistance and aflatoxigenic potentials of isolated fungi.
Methods And Results: Water samples were analysed for risk of contamination, bacteriological and mycological parameters using a standard sanitary survey checklist and microbiological culturing. Isolates were identified and subjected to antifungal resistance profiling using the diffusion method for susceptibility testing of filamentous fungi.
Article Synopsis
- Type 1 diabetes is an autoimmune disease where the body's immune system attacks insulin-producing cells in the pancreas, with type I interferons (IFNs) playing a key role in its development.
- Research on LEW.1WR1 rats showed that infection with Kilham rat virus (KRV) reduces the incidence of diabetes, leading to differences in immune cell populations based on the presence or absence of IFN receptor (IFNAR).
- Flow cytometric analysis indicated decreased CD8 T cells and NK cells in KRV-infected LEW.1WR1 rats, along with an increase in neutrophils and changes in gene expression related to immune cell function, emphasizing the complex immune response following IFNAR loss.
Article Synopsis
- Poor environmental conditions and hygiene practices during childbirth are linked to severe infections and fatalities in mothers and babies.
- The study assessed the water, sanitation, and hygiene (WASH) conditions, as well as infection prevention practices, in 50 traditional birth centers in Abeokuta, Nigeria.
- Findings showed that these centers largely failed to meet WHO standards for environmental health, highlighting the need for improved WASH facilities and IPC practices to enhance maternal and child health, especially as non-facility births remain prevalent.