Publications by authors named "Adebiyi A"

Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.

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Introduction/background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The AF Atrial Fibrillation Registry, which commenced in June 2023, was designed to provide clinical epidemiological data on patients with AF in the country.

Objective(s): The objective is to describe the rationale, design, and early findings from the registry.

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  • Chronic heart failure (CHF) presents distinct gender-specific factors that impact patient care, yet women are underrepresented in related studies, highlighting a need for more focused research.
  • This study examines 1,290 CHF patients to analyze gender differences in causes, comorbidities, treatment, and one-year mortality rates.
  • Findings reveal that men, who made up 55.8% of the study group, generally had worse health outcomes, prevalent comorbidities, and higher mortality rates compared to women, suggesting significant gender disparities in CHF profiles.
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Introduction/background: There is still little data on clinical profile and atrial fibrillation (AF) characteristics in West Africa. Traditionally the risk factor for chronic AF in the sub-region is chronic rheumatic heart disease. However, with the rapid demographic and epidemiologic transition in the sub-region, the risk factors, clinical profile, and complications of AF appear to be changing.

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  • Cholangiocarcinomas are malignant tumors originating from bile duct epithelium and are commonly found in dogs, particularly exotic breeds aged 2-5 years.
  • The study analyzed five cases reported from 2012 to 2021, focusing on clinical signs, blood tests, and postmortem examinations to improve diagnosis techniques.
  • Findings consistently included severe malnutrition, jaundice, anemia, and characteristic neoplastic cell clusters, although early diagnosis is challenging due to a lack of specific early-stage symptoms.
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  • - Wastewater surveillance has proven effective in tracking the spread of SARS-CoV-2, including its variants, particularly at transportation hubs like Toronto Pearson International Airport.
  • - Canadian municipalities, including WWTPs in Ontario, use techniques like qPCR and whole genome sequencing to monitor the virus in wastewater.
  • - Findings from wastewater samples at the airport often identified new viral lineages 1-4 weeks before clinical cases were reported, highlighting the potential for early detection in pandemic response.
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  • Pemetrexed combined with cisplatin is used for cancer treatment, but its effects on kidney toxicity were unclear, prompting a study using mice to investigate kidney injury from these drugs alone and in combination.
  • Mice were divided into four groups and treated with either captisol, pemetrexed, cisplatin, or both drugs together, after which kidney function was assessed through glomerular filtration rate and necropsy.
  • The results showed that the combination treatment significantly increased kidney damage and biomarkers of injury compared to individual treatments, suggesting increased nephrotoxicity when pemetrexed is combined with cisplatin, even at non-lethal doses.
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  • Men of African descent experience the highest rates of prostate cancer, but the genetic factors behind this have not been thoroughly explored.
  • Researchers analyzed genetic data from nearly 4,000 prostate cancer cases and over 3,500 controls across several African countries to identify specific genetic associations related to the disease.
  • The study found 15 significant genetic associations, including four new ones, highlighting that genetic variation in prostate cancer is influenced by unique African alleles, suggesting that more research in diverse populations is crucial for understanding cancer genetics.
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Background: Cardiac disorders are found in about half of cases of Noonan syndrome (NS). The most common congenital heart diseases in this syndrome include pulmonary valvular stenosis obstructive or nonobstructive hypertrophic cardiomyopathy (17%). Biventricular hypertrophic cardiomyopathy (HCM) is very rare in this condition.

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  • Bridges are essential infrastructures that need to adapt to the impacts of climate change, which poses challenges for the construction industry.
  • A 6D Building Information Modeling (BIM) approach, incorporating 3D models, timelines, cost estimates, and carbon emissions, will be developed to effectively manage climate adaptation measures for bridges.
  • Results indicate that 6D BIM significantly improves bridge resilience, aids in project planning and communication, and helps stakeholders evaluate costs and environmental impacts, promoting both sustainability and cost-efficiency.
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  • The study investigates antibiotic resistance genes in bacterial species posing risks to human and animal health, focusing on isolates from humans and poultry in Edo state, Nigeria.
  • A total of 61 isolates were tested, revealing that 77% came from human samples and 23% from poultry, with high phenotypic resistance observed across the board.
  • Whole-genome sequencing and phylogenetic analysis showed close genetic relationships among isolates, providing valuable insights into the nature of antibiotic resistance in these bacteria from a One Health perspective.
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Intimate partner violence (IPV) is a significant challenge that has a profound impact on women, and a contributing factor to its high prevalence is the justification of IPV. Various research works have shown that women's socioeconomic status (SES) is connected to IPV justification. The major objective of this study is to investigate the socioeconomic disparities in justification of IPV by women in Nigeria.

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Purpose: Prostate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa.

Methods: The Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries.

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Accurately determining and classifying different types of skin cancers is critical for early diagnosis. In this work, we propose a novel use of deep learning for classification of benign and malignant skin lesions using dermoscopy images. We obtained 770 de-identified dermoscopy images from the University of Missouri (MU) Healthcare.

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Chronic kidney disease (CKD) is a progressive and long-term condition marked by a gradual decline in kidney function. CKD is prevalent among those with conditions such as diabetes mellitus, hypertension, and glomerulonephritis. Affecting over 10% of the global population, CKD stands as a significant cause of morbidity and mortality.

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Background: Climate change continues to increase the frequency, intensity, and duration of heat events and wildfires, both of which are associated with adverse pregnancy outcomes. Few studies simultaneously evaluated exposures to these increasingly common exposures.

Objectives: We investigated the relationship between exposure to heat and wildfire smoke and preterm birth (PTB).

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Background: Studies of acute heart failure (AHF) outcomes suggest that there are different predictors of mortality depending on region, ethnicity, and gender.

Objective: The purpose of this study was to identify predictors of six months' post discharge outcome among AHF patients in a Nigerian tertiary hospital.

Methods And Materials: This study was a prospective observational study conducted at the cardiology unit of the Department of Medicine at the University College Hospital Ibadan.

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Background: Mitigating the risk of nosocomial infection is one of the core functions of healthcare managers in hospital environments. This study aimed to describe the COVID-19 outbreak response in a tertiary healthcare facility in Nigeria.

Methods: A qualitative cross-sectional study was conducted among representatives of Heads of Infection Control Committees and units, the Accident and Emergency unit, Family Medicine unit, and Private Suites on the COVID-19 outbreak response at the University College Hospital, Ibadan, Nigeria.

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Sepsis is the most frequent risk factor for acute kidney injury (AKI) in critically ill infants. Sepsis-induced dysregulation of kidney microcirculation in newborns is unresolved. The objective of this study was to use the translational swine model to evaluate changes in kidney function during the early phase of sepsis in newborns and the impact of fluid plus norepinephrine resuscitation.

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Background: Hypertension is a medical condition of public health concern that increases the risk of chronic noncommunicable diseases and mortalities. In recent years, understanding its coexistence with other comorbidities has been the focus of better management. However, the relationship between hypertension and depression or anxiety has been contentious issue, with diverse findings reported by different studies.

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It is not uncommon for congenital heart defects to occur in clusters. Those involving a right to left heart shunt commonly cause cyanosis and finger clubbing. Differential clubbing involving only the lower limb digits is a strong pointer to the presence of patent ductus arteriosus with reversal of shunt.

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To celebrate 100 years of American Heart Association-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important mission, 4 principal investigators gathered their efforts to cover distinct yet intricately related areas of signaling mechanisms pertaining to the pathogenesis of hypertension.

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Background: This was a cross-sectional community-based survey to study the prevalence of serum antibodies against the severe acute respiratory syndrome coronavirus 1 (SARS-COV-1) and determine possible source of antibodies as to whether from vaccination or from natural infection as well as attempt to compare antibody levels in response to the different four types of vaccines administered in Nigeria.

Methods: A cross-sectional community-based study of the prevalence of serum antibodies against all four vaccine types used in Nigeria amongst a representative sample of people aged 18 years and above in the six geopolitical zones of the country using a multistage sampling technique covering 12 states of the country with two states being randomly selected from each geopolitical zone. High-throughput Roche electrochemiluminescence immunoassay system (Elecsys Anti-SARS-COV-1 Cobas) was used for qualitative and quantitative detection of antibodies to SARS-COV-1 in human plasma.

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Introduction: There has been an upsurge in the reporting of cases of Left Ventricular Noncompaction (LVNC) cardiomyopathy in medical literature in the last 35 years due to advances in medical imaging.The condition was first described in 1926 and the first reported case by echocardiography was in 1984. The American Heart Association considers LVNC a primary cardiomyopathy of genetic origin, while the European Society of Cardiology and the World Health Organization grouped it as an unclassified cardiomyopathy.

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