Investigating the effect of , on using integrated computational approaches.

Unlabelled: , a notorious member of the ESKAPE pathogens, poses significant public health challenges due to its virulence and multidrug-resistant nature, particularly in methicillin-resistant (MRSA) strains. With the increasing threat of antibiotic resistance, there is an urgent need to develop novel antibiotic agents. This study therefore aims to explore the antibacterial potential of ,-dibenzoylhydrazine (DBH) as a scaffold against drug target enzymes, using integrated computational approaches.

Evaluation of seed oil from Hura crepitans, Trichosanthes cucumerina and Thevetia nerifolia.

The oil contents and fatty acid composition of three non-edible seed oils extracted using Soxhlet extraction with hexane as the solvent were presented. The physical and chemical properties of the oils were determined from which cetane number, biofuel potential, higher heating values, and antimicrobial activities were assessed. The dominant fatty acids were 49 % linoleic acid, 37 % pentadecenoic acid, and 38 % cis-10-heptadecenenoic acid for (HC), (TN) and (TC), respectively.

Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition.

COVID-19 pandemic is currently decimating the world's most advanced technologies and largest economies and making its way to the continent of Africa. Weak medical infrastructure and over-reliance on medical aids may eventually predict worse outcomes in Africa. To reverse this trend, Africa must re-evaluate the only area with strategic advantage; phytotherapy.