Publications by authors named "Addalyn J Burningham"
Background: Preterm birth (PTB) is a leading cause of neonatal mortality, such that the need for a rapid and accurate assessment for PTB risk is critical. Here, we developed a 3D printed microfluidic system that integrated solid-phase extraction (SPE) and microchip electrophoresis (μCE) of PTB biomarkers, enabling the combination of biomarker enrichment and labeling with μCE separation and fluorescence detection.
Results: Reversed-phase SPE monoliths were photopolymerized in 3D printed devices.
Article Synopsis
- Mosquito-borne viruses are a global health concern, but rapid diagnostic methods are often lacking for patients.
- Researchers designed a microfluidic device using a 3D printer that can detect viral RNA and oligonucleotides, specifically targeting the chikungunya virus (CHIKV).
- The device showed strong performance in capturing CHIKV RNA with high specificity, achieving detection limits comparable to those found in acute clinical samples, indicating potential for future diagnostic applications.