Effect of Lactate Minimum Speed-Guided Training on the Fluid, Electrolyte and Acid-Base Status of Horses.

The effect of lactate minimum speed (LMS)-guided training on horses' homeostasis is still unknown. Thus, this study aimed to evaluate the effect of an LMS-guided training program on the fluid, electrolyte and acid-base status of horses. Ten untrained Arabian horses were submitted to an LMS test on a treadmill before and after six weeks of training.

Epidemiology of free-living amoebae infections in Africa: a review.

FLA-related conditions are a rare medical occurrence. Despite their rarity, they are considered a public health concern for two reasons: the absence of a regular treatment regimen in the case of central nervous system infections and the fast progression of the symptoms leading to fatal outcomes. A total of 358 articles were retrieved from different databases (91 from PubMed, 26 from NCBI, 138 from Academia, 102 from Science Direct, and one from IJMED).

Effect of Lactate Minimum Speed-Guided Conditioning on Selected Blood Parameters of Horses.

During exercise, equines can suffer severe water and electrolyte imbalances depending on the intensity and duration. In this sense, conditioning aims to promote adaptations to the organism in order to maintain cardiovascular and thermoregulatory stability during exertion. This study aimed to evaluate the effect of conditioning guided by lactate minimum speed (LMS) test on the blood osmolality of horses.

Characterization of novel, recurrent genomic rearrangements as sensitive MRD targets in childhood B-cell precursor ALL.

B-cell precursor (BCP) ALL carry a variety of classical V(D)J rearrangements as well as genomic fusions and translocations. Here, we assessed the value of genomic capture high-throughput sequencing (gc-HTS) in BCP ALL (n = 183) for the identification and implementation of targets for minimal residual disease (MRD) testing. For TRδ, a total of 300 clonal rearrangements were detected in 158 of 183 samples (86%).

Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL.

Comprehensive next-generation sequencing (NGS) applications have recently identified various recurrent kinase and cytokine receptor rearrangements in Ph-like B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) amenable to tyrosin kinase inhibitor treatment. For rapid diagnostics of kinase pathway aberrations in minimal residual disease (MRD) high-risk BCP-ALL, we developed a PCR-independent NGS custom enrichment capture panel targeting recurrent genomic alterations, which allows for the identification of unknown 5' fusion partner genes and precise mapping of variable genomic breakpoints. Using a standardized bioinformatics algorithm, we identified kinase and cytokine receptor rearrangements in the majority of ALL patients with high burden of postinduction MRD and enrichment of IKZF1 mutation or deletion (IKZF1(del) ).

Percutaneous aortic valvuloplasty in inoperable symptomatic severe aortic stenosis in the very elderly.

Aortic valve replacement is the first therapeutic option in patients with symptomatic severe aortic stenosis. Given the fact that percutaneous aortic valve implantation is a relatively new procedure and the need for palliative treatment in symptomatic patients with a high surgical risk, percutaneous balloon aortic valvuloplasty is still employed. The authors describe two cases of percutaneous balloon aortic valvuloplasty in very elderly patients with severe calcified aortic stenosis not suitable for cardiac surgery, exacerbated in one case by significant coronary artery disease and left ventricular systolic dysfunction.

Anomalous origin of the circumflex coronary artery--two case reports.

As shown in many series, congenital coronary artery anomalies are found in 0.6 to 1.5% of patients undergoing coronary angiography.

Small coronary arteries treated with sirolimus-eluting stents: one-year results of the PORTO multicentre registry.

Aims: To assess the effectiveness and safety of sirolimus-eluting stents (SES) in de novo native coronary lesions in small vessels (
Methods And Results: PORTO was a multicentre, prospective registry, performed in 274 patients.

Contact-line friction of liquid drops on self-assembled monolayers: chain-length effects.

The static and dynamic wetting properties of self-assembled alkanethiol monolayers of increasing chain length were studied. The molecular-kinetic theory of wetting was used to interpret the dynamic contact angle data and evaluate the contact-line friction on the microscopic scale. Although the surfaces had a similar static wettability, the coefficient of contact-line friction zeta0 increased linearly with alkyl chain length.

Dynamics of the rise around a fiber: experimental evidence of the existence of several time scales.

We study experimentally the dynamics of the spontaneous rise of a meniscus made of polydimethylsiloxane of various viscosities on the outside of a micrometric fiber made of monofilament in polyethyleneterephthalate. Optical methods are used to measure simultaneously the height of the liquid interface and the associated contact angle versus time. Versus the liquid viscosity, we observe asymptotically, for the dynamic contact angle, either a t(-1/2) behavior in agreement with the hydrodynamic description or a t(-1) behavior predicted by the molecular-kinetic theory, in its linear form, thus confirming the existence of at least two major time scales in the rise phenomenon.

Acute coronary syndromes in smokers: clinical and angiographic characteristics.

Unlabelled: Smoking is a major and reversible risk factor for coronary artery disease. The present work aims to define the risk factors, angiographic and clinical characteristics and evolution of acute coronary syndromes in smokers.

Methods: We studied 521 consecutive patients with acute coronary syndrome admitted to the intensive care unit who underwent catheterization.

Percentage of coronary anomalies in a population of patients undergoing coronary angiography: a retrospective study.

Coronary artery anomalies, although less frequent than congenital anomalies of the heart chambers and valve morphology, should be considered in a wide range of ages, in both sexes and as a possible etiology in myocardial ischemia, infarction, and sudden death, as well as in the planning of heart surgery for coronary revascularization, correction of congenital heart malformations or valve replacement. Between January 1996 and June 2002 we reviewed our catheterization database and carried out a retrospective study of the 3660 angiographies performed in our cardiology department. The patients were referred for positive ischemic test, acute coronary syndrome and/or valvular heart disease.

Left main coronary artery originating in the right sinus of Valsalva.

A forty-one-year-old male, with no risk factors for coronary artery disease (CAD) and with moderate alcohol intake, was admitted in 1992 to Portalegre Hospital with heart failure due to viral cardiomyopathy. He was re-admitted in 1998 with acute pulmonary edema and was put on mechanical ventilation for 48 hours, and transferred to Pulido Valente Hospital when stable. The physical exam was without abnormalities.

New classification of aortic dissection with reference to a case report.

The authors present a case report of a patient who was diagnosed with aortic dissection during a hemodynamic exam following acute myocardial infarction. With reference to this case, the European Society of Cardiology's latest classification of aortic dissection, published in 2001, is also presented. The patient had the usual risk factors described for aortic dissection, which are simultaneously those for coronary disease.

[Prognosis significance of blood homocysteine after myocardial infarction].

Introduction And Aims: Homocysteinemia is an independent risk factor of coronary artery disease and of myocardial infarction. In the present study we intend to relate fasting homocystein levels to prognosis after a myocardial infarction.

Methods: From 1990 to 1992, we studied fasting homocysteinemia levels on a group of 112 patients aged under 56 years that had suffered a myocardial infarction between 3 and 12 months before.

Estimation of the Surface Properties of Styrene-Acrylonitrile Random Copolymers from Contact Angle Measurements.

The surface free energy per unit area of a solid, gamma(S), is a fundamental property of materials and determines their surface and interfacial behavior in processes like wetting and adhesion. In this study the gamma(S) of a series of styrene-acrylonitrile random copolymers is evaluated. Three different approaches are used to determine the components in which the surface free energy can be decomposed.

[Cardiac amyloidosis: review of the literature].

The authors review the clinical impact of cardiac amyloidosis and new aspects concerning the management of this disease in the literature. Cardiac amyloidosis accounts for 5-10% of non-coronary myocardial disorders. It is a distinct form of cardiomyopathy with a severe prognosis.

[Pharmacological stimulation with dipyridamole in thallium-201 myocardial perfusion scintigraphy: a study of the secondary effects].

To evaluate the safety of intravenous dipyridamole thallium-201 imaging as an alternative to exercise thallium imaging in the evaluation of coronary artery disease, clinical data from 140 patients were retrospectively analyzed. Adverse effects were experienced by 39 patients (27.9%) with a total number of 52 effects: chest pain (23), dizziness (13), headache (7), nausea (7), dyspnea (2).

Homocysteinaemia after methionine overload as a coronary artery disease risk factor: importance of age and homocysteine levels.

Background: Homocysteinaemia is now accepted as an independent risk factor for coronary artery disease (CAD). Our goal was to study the influence of age plasma homocysteine level on the CAD risk attributable to homocysteinaemia.

Methods: We studied a group of 98 patients under 55 years of age who had suffered a myocardial infarction 3-12 months before the study.