Publications by authors named "Adane Ayele"
Bilateral agminated skin-colored papules and nodules on the dorsum of the hands.
Indian J Dermatol Venereol Leprol
June 2019
Lipodermatosclerosis (LDS) is a well-recognized form of fibrosing panniculitis. Although chronic cases are readily diagnosed, early and evolving lesions may be clinically mistaken for cellulitis and other forms of panniculitis. Most pathologists are familiar with a pseudomembranous type of fat necrosis as a useful feature of chronic LDS.
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- Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are inflammatory skin diseases where the cytokine IL-22 plays a significant role in their development, and the research investigates the involvement of prostaglandin E (PGE) in this process.
- PGE was found to induce IL-22 production in T cells through specific receptors (EP2 and EP4) and cyclic AMP signaling, which is vital for inflammation linked to ACD.
- The study highlights that PGE and IL-22 signaling pathways are elevated in AD skin, suggesting that targeting these pathways could be a potential strategy for treating these skin conditions.
Background: Patch testing is essential to diagnose allergic contact dermatitis. Dermatologists in many countries use a baseline (standard) series covering the major allergens responsible for allergic contact dermatitis in their population, with the addition of relevant allergens for the individual patient. However, a baseline series has not yet been developed for Ethiopia.
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