Publications by authors named "Adan Ton-Loy"
APOE×BDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
J Neuropsychiatry Clin Neurosci
October 2024
Objective: The authors examined the interaction between apolipoprotein E (APOE) ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles on neuropsychological functioning among veterans with histories of mild traumatic brain injury (mTBI).
Methods: Participants were 78 veterans with mTBI (85% males; mean±SD age=32.95±7.
Objective: Identifying factors that moderate cognitive outcomes following mild traumatic brain injury (mTBI) is crucial. Prospective memory (PM) is a cognitive domain of interest in mTBI recovery as it may be especially sensitive to TBI-related changes. Since studies show that genetic status - particularly possession of the apolipoprotein E (APOE) ε4 allele - can modify PM performance, we investigated associations between mTBI status and APOE-ε4 genotype on PM performance in a well-characterized sample of Veterans with neurotrauma histories.
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- The study investigates how different criteria for diagnosing mild cognitive impairment (MCI) in Vietnam-era Veterans can predict progression to Alzheimer's disease (AD), particularly focusing on those with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD).
- Researchers found that neuropsychological criteria were more effective at identifying MCI and showed a stronger link to AD biomarkers compared to typical Petersen/Winblad and ADNI criteria, especially in Veterans with TBI or PTSD.
- The findings suggest that using thorough neuropsychological assessments could improve MCI diagnosis in Veterans, highlighting the importance of considering PTSD impacts alongside conventional diagnostic methods.
Objective: To examine relationships between performance validity testing (PVT), neurobehavioral symptom endorsement, and symptom attribution in Veterans with a history of mild traumatic brain injury (mTBI).
Method: Participants included treatment-seeking Veterans (n = 37) with remote mTBI histories who underwent a neuropsychological assessment and completed a modified version of the Neurobehavioral Symptom Inventory (NSI) to assess symptom endorsement and symptom attribution (the latter evaluated by having Veterans indicate whether they believed each NSI symptom was caused by their mTBI). Veterans were divided into two subgroups, PVT-Valid (n = 25) and PVT-Invalid (n = 12).