Clozapine Safety in Pregnancy: A Clinical Study.

Background And Hypothesis: Pregnant women with persistent schizophrenia and related disorders may require ongoing antipsychotic treatment, including clozapine. However, the potential risks of using clozapine during pregnancy and the postnatal period remain uncertain.

Study Design: We conducted a nested case-control study using the National Register of Antipsychotic Medication in Pregnancy (NRAMP) database.

Good at heart: Developing a tertiary perinatal cardiac service; the first eight years of experience.

Background: Maternal cardiac disease is the most common cause of indirect maternal death, and women with pre-existing cardiac disease have complex medical, obstetric and anaesthetic requirements. Our hospital commenced a multidisciplinary perinatal cardiac service in 2009 to optimise outcomes in women with cardiac disease.

Aim: To assess the maternal and perinatal outcomes of women referred to the clinic to evaluate clinical practice and inform future service provision.