Publications by authors named "Adam W T Steffeck"
Circadian Dysfunction in the Skeletal Muscle Impairs Limb Perfusion and Muscle Regeneration in Peripheral Artery Disease.
Arterioscler Thromb Vasc Biol
December 2024
Article Synopsis
- Peripheral artery disease (PAD) affects mobility due to reduced blood flow caused by atherosclerosis, and studies indicate that disruptions in circadian rhythms may impact vascular repair, particularly in limb ischemia situations.
- This study explores the impact of the skeletal muscle circadian clock on adaptations to ischemic stress using a mouse model, focusing on the role of the circadian clock activator BMAL1 in muscle recovery after surgery-induced limb ischemia.
- Findings revealed that circadian rhythm-related genes were altered in PAD patients, and the loss of BMAL1 in mice delayed muscle recovery post-ischemia, resulting in fewer regenerated muscle fibers and a decline in specific muscle fiber types.
The process of tissue regeneration occurs in a developmentally timed manner, yet the role of circadian timing is not understood. Here, we identify a role for the adult muscle stem cell (MuSC)-autonomous clock in the control of muscle regeneration following acute ischemic injury. We observed greater muscle repair capacity following injury during the active/wake period as compared with the inactive/rest period in mice, and loss of within MuSCs leads to impaired muscle regeneration.
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