Publications by authors named "Adam W Cheely"
Article Synopsis
- IKKε and TBK1 are lesser-known kinases involved in inflammation and cancer, but effective inhibitors are scarce.
- The study identifies TBK1's optimal phosphorylation motif, which matches that of IKKε, enabling the development of a substrate peptide for screening.
- A high-throughput screening of a 6,006 compound library led to the discovery of 227 TBK1 inhibitors and 57 IKKε inhibitors, paving the way for potential treatments for inflammatory diseases and cancer.
Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male reproductive tract. In this study we investigated the regulation and function of Nod2 in epididymal epithelial cells following lipopolysaccharide (LPS) stimulation.
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