Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings.

Recurrent oral infections, as manifested by endodontic and periodontal disease, are often caused by () and (). Here, we assessed the anti-biofilm activity of ceragenin CSA-44 against these microbes growing as a biofilm in the presence of saliva on the surface of human teeth and dental composite (composite filling) subjected to mechanical stresses. Biofilm mass analysis was performed using crystal violet (CV) staining.