Publications by authors named "Adam S Bassett"
Article Synopsis
- Bovine congestive heart failure (BCHF) is increasingly common in feedlot cattle, leading to high mortality rates, and the study aimed to identify genetic factors associated with this untreatable condition.
- Researchers conducted a genome-wide association study comparing 102 BCHF cases with unaffected pen mates, analyzing around 560,000 genetic markers.
- Significant associations were found with two genes, leading to the conclusion that specific genetic variants can greatly increase the likelihood of BCHF, suggesting potential DNA tests for identifying at-risk cattle.
Bovine congestive heart failure (BCHF) has become increasingly prevalent in feedlot cattle in the Western Great Plains of North America. BCHF is an untreatable complex condition involving pulmonary hypertension that culminates in right ventricular failure and death. A protein variant of hypoxia-inducible factor 2 alpha (HIF2α, encoded by the endothelial PAS domain-containing protein 1 gene, ) was previously reported to be associated with pulmonary hypertension at altitudes exceeding 2,000 m.
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