NMDA receptor antagonism with MK-801 impairs consolidation and reconsolidation of passive avoidance conditioning in adolescent rats: evidence for a state dependent reconsolidation effect.

The characteristics of memory consolidation, reconsolidation, and state dependency have received considerable attention for many years. Three experiments examined the effects of the NMDA antagonist MK-801 on these phenomena in adolescent rats using passive avoidance conditioning. Experiment 1 demonstrated that immediate post-training administration of MK-801 produced a consolidation impairment at postnatal day 37.