An industrial perspective on co-crystals: Screening, identification and development of the less utilised solid form in drug discovery and development.

Active pharmaceutical ingredients are commonly marketed as a solid form due to ease of transport, storage and administration. In the design of a drug formulation, the selection of the solid form is incredibly important and is traditionally based on what polymorphs, hydrates or salts are available for that compound. Co-crystals, another potential solid form available, are currently not as readily considered as a viable solid form for the development process.

Charge-modulated self-assembly and growth of conjugated polyelectrolyte-polyoxometalate hybrid networks.

Self-assembly of an anionic polyoxometalate with cationic conjugated polyelectrolytes leads to hybrid supramolecular networks whose dimensionality is controlled by the chain length and steric charge distribution.

Sterically-controlled regioselective para-substitutions of aniline.

Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.