Publications by authors named "Adam Nightingale"
Drug Deliv Transl Res
February 2025
Article Synopsis
- Gerresheimer and Midas Pharma created a new autoinjector design that uses a cartridge kept under constant pressure, and analyzed the primary packaging materials for performance over time.
- The study involved testing materials from three glass manufacturers and two rubber manufacturers, focusing on how they behave under long-term pressure regarding septum stability, piercing ability, glide and break-loose forces, and the integrity of a marketed antibody drug.
- Results showed that while the cartridge septum initially bulged, it stabilized after 14 days, and no significant issues such as septum rupture or degradation of the drug were observed, indicating the design is safe and effective even under prolonged pressure.
