Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F:Tb(Gd),Yb,Nd Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography.

Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, - and ( *)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(,-dimethylacrylamide--acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F:Tb(Gd),Yb,Nd nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer.