Publications by authors named "Adam M Hamilton"
Article Synopsis
- Recent studies show that people with Parkinson's disease experience significant changes in their gut microbiome, which could worsen their condition.
- Research is exploring how restoring or modifying the gut microbiome through methods like fecal transplants, prebiotics, and probiotics might help manage PD symptoms.
- Ongoing clinical trials aim to better understand how specific gut bacteria can influence Parkinson's disease, indicating a promising link between laboratory findings and potential therapies for patients.
Article Synopsis
- Spinal cord injury (SCI) leads to various problems, particularly affecting the gut and causing issues like intestinal dysmotility and atrophy of the enteric nervous system (ENS).
- New research suggests that changes in gut microbiome due to SCI might be linked to these gut issues, and that dietary interventions could help aid recovery.
- Specifically, using dietary fiber such as inulin can prevent ENS damage and help restore gut function in injured mice, highlighting a connection between diet, gut bacteria, and immune response that could inform future treatments for bowel problems following spinal injuries.
Spinal cord injury (SCI) results in a plethora of physiological dysfunctions across all body systems, including intestinal dysmotility and atrophy of the enteric nervous system (ENS). Typically, the ENS has capacity to recover from perturbation, so it is unclear why intestinal pathophysiologies persist after traumatic spinal injury. With emerging evidence demonstrating SCI-induced alterations to the gut microbiome composition, we hypothesized that modulation of the gut microbiome could contribute to enteric nervous system recovery after injury.
View Article and Find Full Text PDFIncreasing evidence indicates that neurodegenerative diseases, including Alzheimer's disease (AD), are a product of gene-by-environment interplay. The immune system is a major contributor mediating these interactions. Signaling between peripheral immune cells and those within the microvasculature and meninges of the central nervous system (CNS), at the blood-brain barrier, and in the gut likely plays an important role in AD.
View Article and Find Full Text PDFTraumatic spinal cord injury and the contributions of the post-injury microbiome.
Int Rev Neurobiol
November 2022
Spinal cord injuries are an enormous burden on injured individuals and their caregivers. The pathophysiological effects of injury are not limited to the spine and limb function, but affect numerous body systems. Growing observations in human studies and experimental models suggest that the gut microbiome is altered following spinal cord injury.
View Article and Find Full Text PDFParkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers. We tested this by inoculating the duodenal wall of mice with α-Syn preformed fibrils.
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