Publications by authors named "Adam Koebel"
Limited tumor nanoparticle accumulation remains one of the main challenges in cancer nanomedicine. Here, we demonstrate that subtherapeutic photodynamic priming (PDP) enhances the accumulation of nanoparticles in subcutaneous murine prostate tumors ∼3-5-times without inducing cell death, vascular destruction, or tumor growth delay. We also found that PDP resulted in an ∼2-times decrease in tumor collagen content as well as a significant reduction of extracellular matrix density in the subendothelial zone.
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- Subtle biochemical changes in brain myelin can provoke immune responses resembling multiple sclerosis (MS) lesions.
- A specific experiment using cuprizone treatment showed that the level of myelin damage influenced the intensity of immune reactions, where both minimal and excessive damage did not lead to significant issues.
- The use of an enzyme inhibitor during myelin alteration lessened pathology, suggesting that targeting myelin could be a vital approach for early treatment and prevention of MS.
Peptidyl arginine deiminases have been shown to be hyperactive in neurodegenerative diseases including multiple sclerosis. An α-amino acid-based core structure, derived from a hydantoin core, with unique heterocycles on the side chains were synthesized as potential noncovalent inhibitors of PAD enzymes. Among the various heterocycles investigated, compound 23, carrying an imidazole moiety, exhibited the highest potency in this series with some selectivity for PAD2, and was further investigated in vivo.
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