Publications by authors named "Adam Kerry Dobbs"
Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies.
Djuro Karanovic Ian C Michelow Anthony R Hayward Suk See DeRavin Ottavia M Delmonte Adam Kerry Dobbs
Front Immunol
December 2019
Article Synopsis
- Phosphoinositide 3-kinase (PI3K) is crucial for lymphocyte function, and mutations in its p110δ and p85α subunits lead to heightened activity and immune issues.
- The text discusses unique cases of a mother and child both suffering from severe toxoplasmosis due to a shared mutation affecting PI3K.
- It examines how this mutation and similar ones contribute to an increased risk of severe infections in activated PI3Kδ syndrome (APDS) and other primary immunodeficiencies.