Cytogenomic aberrations in isolated multicystic dysplastic kidney in children.

Background: Multicystic dysplastic kidney (MCDK) is a common form of congenital kidney anomaly. The cause of MCDK is unknown. We investigated whether MCDK in children is linked to cytogenomic aberrations.

Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension.

Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells (NPCs) of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump V-ATPase. Previously, we demonstrated that conditional ablation of the PRR in Six2 NPCs in mice (Six2 ) causes early neonatal death.

Prorenin receptor controls renal branching morphogenesis via Wnt/β-catenin signaling.

The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump H-ATPase. Renal branching morphogenesis, defined as growth and branching of the ureteric bud (UB), is essential for mammalian kidney development. Previously, we demonstrated that conditional ablation of the in the UB in mice causes severe defects in UB branching, resulting in marked kidney hypoplasia at birth.