Genetic and protein changes of E-cadherin in meningiomas.

Purpose: The molecular mechanisms and candidate genes involved in development of meningiomas still needs investigation and elucidation.

Methods: In the present study 60 meningiomas were analyzed regarding changes of tumor suppressor gene E-cadherin (CDH1), a component of adherens junction and an indirect modulator of the wnt signaling. Gene instability was tested by polymerase chain reaction/loss of heterozygosity (LOH) method.