Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.

Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially considered among those at highest risk for serious harm from SARS-CoV-2 infection. Numerous clinical studies have subsequently reported that individuals with CF in North America and Europe-while susceptible to severe COVID-19-are often spared from the highest levels of virus-associated mortality. To understand features that might influence COVID-19 among patients with cystic fibrosis, we studied relationships between SARS-CoV-2 and the gene responsible for CF (i.

Patient-predicted sleep position vs. HST data: a tendency to underestimate supine sleep.

Purpose: The purpose of this study is to measure people's accuracy when they estimate what proportion of their nightly sleep at home is supine vs. non-supine.

Methods: A series of patients referred for obstructive sleep apnea (OSA) evaluation were asked if they "knew with confidence" how they slept with regard to their body position.

Insomnia: Getting to the cause, facilitating relief.

Chronic insomnia is often the result of multiple underlying physiologic, psychological, and social factors. A sleep log, sleep hygiene, CBT, and medication can help.

Recognizing and managing insomnia in primary care and specialty settings.

Insomnia is a common feature of both medical and psychiatric disorders. Whether as a symptom of an illness or as a comorbid disorder, insomnia worsens patient outcomes related to quality of life, functioning, workplace productivity, and health care expenditures. This CME webcast covers how to screen for insomnia in patients with both medical and mental illnesses and how to develop a comprehensive treatment plan.

Development and growth of a large multispecialty certification examination: sleep medicine certification--results of the first three examinations.

This paper summarizes the results of the first three examinations (2007, 2009, and 2011) of the Sleep Medicine Certification Examination, administered by its six sponsoring American Board of Medical Specialty Boards. There were 2,913 candidates who took the 2011 examination through one of three pathways-self-attested practice experience, previous certification by the American Board of Sleep Medicine, or formal Sleep Medicine fellowship training. The 2011 exam was the last administration in which candidates who had not previously been admitted could take it without completion of formal Sleep Medicine fellowship training.

Frequency of provision of CPAP in the inpatient setting: an observational study : "CPAP provision in the inpatient setting".

Background: Little is known about the rates of provision of CPAP in inpatient settings. A single prior "data mining" study using diagnostic and procedural codes concluded that 6% of people with sleep apnea receive CPAP when in the hospital. The purpose of this study is to reexamine the frequency with which people who have an established diagnosis of sleep apnea receive therapy for it when they are admitted to the hospital for other reasons.

How is your sleep: a neglected topic for health care screening.

Purpose: Inadequate sleep, whether it is caused by voluntary sleep curtailment or specific sleep disorders, is highly prevalent, has wide-ranging negative consequences for human health and well-being, and is greatly under-diagnosed. The objective of this study was to determine the frequency of inquiry by family medicine clinics about unhealthy sleep patterns and symptoms in their health history database questionnaires.

Methods: This study surveyed health history database forms used by family medicine clinics in the 7-county Minneapolis/St.