Publications by authors named "Adam Huxley"

Throughout the COVID-19 pandemic, and beyond for many businesses, employees have had to adapt to new ways of working due to disruptions in traditional practices. It is therefore crucial to understand the new challenges that employees are facing when it comes to taking care of their mental wellbeing at work. To that end, we distributed a survey to full-time UK employees (N = 451) to explore how supported they felt throughout the pandemic, and to identify whether there are any additional types of support they would like to receive.

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Purpose: People living with psychotic illness disproportionately experience more comorbidities and have a markedly shorter life expectancy compared to the general population. This review evaluates the effectiveness of health behavior change interventions in improving health outcomes in this group.

Design And Methods: All studies included objective physical health measures or health behaviors as the main outcome measures and experimental design with baseline and follow-up quantitative data.

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An inability to experience pleasure or a reduction in the ability to do so is a prominent feature of schizophrenia that is often included among the negative symptoms of the disorder. As a whole, dysfunction in the affective experience of pleasure in patients with schizophrenia is poorly understood and is mediated by a number of cognitive and emotional processes. Whilst there is evidence that patients with schizophrenia have an impaired ability to derive and experience pleasure from non-current tasks, there is some evidence that they report current pleasurable experiences similar to non-clinical control participants.

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Objective: This study identified predictors of psychosocial outcome in schizophrenia.

Method: A mixed group of patients diagnosed with schizophrenia were assessed as part of a routine clinical evaluation. A linear regression analysis was conducted in order to examine the effect of duration of untreated illness, number of previous hospitalisations, history of psychotic episodes and age at illness onset on patients' functioning, as assessed with the Global Assessment of Functioning (GAF) scale.

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To explore whether cognitive impairment and global functioning can predict the degree of insight into illness as well as whether insight is mediated by specific symptom dimensions of psychopathology in schizophrenia. A dimensional/cross sectional approach was used. A mixed group of clients (n = 36) were assessed as part of a routine clinical evaluation.

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Background: Donepezil Hydrochloride (Aricept) is a selective anticholinesterase inhibitor developed for the treatment of Alzheimer's disease (AD). This study investigated the safety and efficacy of the drug to treat Down syndrome (DS) adults with mild to moderate AD.

Method: This was a 24-week, double blind, placebo controlled, parallel-group trial.

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