Publications by authors named "Adam Humble"
Article Synopsis
- - The study focuses on Rac2 guanosine triphosphatase's crucial role in the process of neutrophil degranulation, specifically how it influences the release of different types of granules in response to immune stimuli.
- - Neutrophils lacking Rac2 showed impaired release of primary granules, like myeloperoxidase, but not secondary or tertiary; they also had reduced actin remodeling protein (coronin 1A) and exhibited less cellular structural changes like filopodia formation.
- - The research concludes that Rac2 not only regulates immune complex-stimulated granule exocytosis but also plays a role in granule polarization and actin cytoskeleton rearrangement in neutrophils
