Publications by authors named "Adam G Barron"
Article Synopsis
- Previous research identified Q8009, a protease from the venom of the Australian brown snake, known for its Factor Xa-like activity and ability to promote blood clotting.
- The current study evaluated Q8009's effectiveness in reducing blood loss and speeding up clotting in rats with injuries to the spleen, liver, and kidney, finding it significantly improved results compared to thrombin.
- Results showed that Q8009 significantly decreased total blood loss and time-to-hemostasis across all organ models, demonstrating its potential as a more effective hemostatic agent than traditional treatments.
Objective: Nephrogenic systemic fibrosis (NSF) is a clinical syndrome linked with exposure in renal failure patients to gadolinium-based magnetic resonance imaging contrast agents (GBCAs). The pathogenesis of the disease is largely unknown. The present study addresses potential pathophysiological mechanisms.
View Article and Find Full Text PDFMice on a calorie-restricted (CR) diet (total calories restricted to 70% of ad libitum; AL) for periods of time ranging from 3 to 18 months were examined for response to topical treatment with all-trans retinoic acid (RA). Daily application of a 0.1% solution of RA to the shaved skin of UM-HET3 mice on an AL diet produced a severe irritation that was evident by day 4, maximal at day 7-8 and still detectable at day 14.
View Article and Find Full Text PDFArticle Synopsis
- Wegener's Granulomatosis (WG) is an autoimmune condition that mainly impacts small blood vessels, leading to kidney and lung issues.
- The study aimed to create an antibody array to analyze protein expression in the serum of WG patients compared to healthy individuals, focusing on those that are age and sex matched.
- The results showed significant increases in 24 proteins related to vascular injury in WG patients, suggesting potential biomarkers for better understanding and diagnosing the disease.
Article Synopsis
- Researchers investigated the hemostatic effects of a factor Xa-like protease (Q8009) from the Australian snake Pseudonaja textilis textilis using models of tail-tip transection and dermal incision.
- Findings showed that adding Q8009 with a collagen matrix significantly decreased blood loss and improved time-to-hemostasis compared to Thrombin, especially in the dermal incision model.
- In tail-tip injuries, soaking in a Q8009 solution led to a dramatic reduction in blood loss and quicker hemostasis compared to Thrombin, highlighting Q8009's potential as a better alternative for controlling bleeding.
Article Synopsis
- Scientists wanted to find out how a substance called interleukin-6 (IL-6) affects a type of disease called granulomatous vasculitis.
- They used two groups of mice: one group that had IL-6 and one that didn’t, and they injected them with a substance from yeast to see how their bodies reacted.
- The results showed that both groups had similar numbers of immune cells and problems in their lungs, suggesting that IL-6 might help a little but isn't super important for the development of this disease.
Article Synopsis
- Previous research indicated that Interleukin-6 (IL-6) might be a marker for vasculitis, prompting further investigation into its role in immune complex-induced vascular injury models with both IL-6 deficient and sufficient mice.
- Elevated IL-6 levels were found in the plasma of injured IL-6 sufficient mice with acute conditions, while IL-6 deficient mice displayed low or undetectable levels.
- Despite the differences in IL-6 levels, histological analyses showed no significant variation in vascular injury, permeability, or immune cell influx between the IL-6 deficient and sufficient groups, suggesting that IL-6 is not critical for the vascular inflammatory response.