Looking for neuronal currents using MRI: an EEG-fMRI investigation of fast MR signal changes time-locked to frequent focal epileptic discharges.

Rationale: Reproducible direct measurement of neuronal electrical activity using MRI signal changes due to local magnetic field perturbations would represent a step change in neuroimaging methods. While some previous studies using experiments based on evoked and spontaneous activity provided encouraging results no clear demonstration of neuronal current-related MR changes in the human brain has emerged to date. The availability of simultaneously acquired EEG-fMRI in patients with frequent interictal epileptic discharges (IED), which have significantly greater amplitude than evoked potentials, offers the opportunity to further investigate the phenomenon.

Analysis of EEG-fMRI data in focal epilepsy based on automated spike classification and Signal Space Projection.

Simultaneous acquisition of EEG and fMRI data enables the investigation of the hemodynamic correlates of interictal epileptiform discharges (IEDs) during the resting state in patients with epilepsy. This paper addresses two issues: (1) the semi-automation of IED classification in statistical modelling for fMRI analysis and (2) the improvement of IED detection to increase experimental fMRI efficiency. For patients with multiple IED generators, sensitivity to IED-correlated BOLD signal changes can be improved when the fMRI analysis model distinguishes between IEDs of differing morphology and field.

The MR detection of neuronal depolarization during 3-Hz spike-and-wave complexes in generalized epilepsy.

Previously, an analysis of activations observed in a patient with idiopathic generalized epilepsy using electroencephalogram-correlated functional magnetic resonance imaging (MRI) during runs of 3-Hz generalized spike-wave discharge (GSWD) was presented by Salek-Haddadi. Time-locked, bilateral, thalamic blood oxygenation level-dependent increases were reported to be accompanied by widespread, symmetric, cortical deactivation with a frontal maximum. In light of recent investigations into MRI detection of the magnetic field perturbations caused by neuronal current loops during depolarization, we revisited the analysis of the data of Salek-Haddadi as a preliminary search for a neuroelectric signal.

Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method.

Electrical impedance tomography (EIT) is a recently developed technique which enables the internal conductivity of an object to be imaged using rings of external electrodes. In a recent study, EIT during cortical evoked responses showed encouraging changes in the raw impedance measurements, but reconstructed images were noisy. A simplified reconstruction algorithm was used which modelled the head as a homogeneous sphere.